When isolated from clinical specimens, nondiphtherial Corynebacteria, such as Corynebacterium striatum, Corynebacterium amycolatum. ABSTRACT. We describe an unusual cluster of Corynebacterium striatum infections in 21 patients with chronic obstructive pulmonary disease (COPD) admitted. Objective: To evaluate the clinical significance of and describe factors associated with Corynebacterium striatum infection. Methods: A.

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Corynebacterium – Wikipedia

Thereby, the QRDR at that gene was amplified and sequenced as previously described Pathogenic species in other animals include C. Table of Contents Alerts. Antimicrobial susceptibility assays Antimicrobial susceptibilities were determined by micro-dilution in stratum adjusted Muller-Hinton broth and interpreted following Clinical and Laboratory Standards Institute CLSI guidelines Among the 31 MDR isolates, 19 resistance profiles could be distinguished.

However, the optimal antimicrobial therapy for these infections is still controversial. Other mechanisms such as active efflux of the antimicrobial and reduced intake into the bacterial cell can contribute to streptomycin resistance in these isolates.

We obtained XbaI macro-restriction patterns of the 63 C.

The presence of aminoglycoside modifying enzyme AME genes common in Corynebacterium spp. PFGE is considered the gold standard in epidemiological studies of pathogenic microorganisms, providing important insights into their population structure Ten of our strains carried the erm B and erm X genes simultaneously, a characteristic previously reported only in one strain of C.


The Corynebacteria are divided into two groups: This article has been cited by other articles in PMC. Therefore, in this case, appropriate antibiotics could not be judged in vivo. She had two comorbidities: The gene aac 3 -XI was found in 7 isolates.

The illness progressed to disseminated intravascular coagulation DIC and disturbance of consciousness on day 67 of admission.

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They may also appear elliptical. Actinobacteria primarily A00—A79—, sfriatum Thus, several outbreaks of clonal multidrug-resistant C. How to cite this URL: This method is based on the assessment of biochemical properties. A variety of Gram-positive bacteria carry mobile mef genes. However, in recent years, they have been reported as emerging opportunistic pathogens in immunocompromised patients with end-stage cancer, hematologic malignancy, and critical condition [ 2 ].

Atriatum Journal of General and Applied Microbiology. Accurate diagnosis of the infection and prompt management helped in a favourable outcome for the patient. J Clin Microbiol ; Although the biochemical properties of C. In phylogenetic trees based on concatenated protein sequences or 16S rRNA, the genus Corynebacterium forms a distinct clade, within which is a distinct subclade, cluster I.

We describe the high incidence of drug resistance in our C. Medically relevant Corynebacterium species include Corynebacterium diphtheriaethe primary cause of diphtheria, and the non-diphtherial corynebacteria, which are part of the normal flora of the skin and mucous membranes. Some asynergy in wall motion was detected by echocardiography, but no vegetation was seen.


Case Reports in Infectious Diseases

Necrotizing fasciitis of lower limb by Corynebacterium Striatum in a HbsAg positive patient. Vancomycin is still active today and therefore it represents an adequate option for treatment of severe infections caused by C. PCR reactions were performed as previously described Fluoroquinolones have been intensively used at the FHU hospital during the last two decades. Van Hoek AH, et al.

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Ishiwada N, et corhnebacterium. Shah M, Murillo JL. Additionally, 16 conserved signature proteins, which are uniquely found in Corynebacterium species, have been identified. In fourteen of the 21 fluoroquinolone-resistant C.

Supplementary information accompanies this paper at doi: Patient-to-patient spread of a single strain of Corynebacterium striatum causing infections in a surgical intensive care unit.